کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844140 | 1127558 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Copper and homocysteine in cardiovascular diseases
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کلمات کلیدی
ADMAAsymmetric dimethyl-arginineCGLS-adenosylhomocysteineMTHFRBHMTCeruloplasminSAHHcyCBSSTZeNOSCCONOSSAMHIF-1DRIHDLcystathionine γ-lyase - cystationine γ-lyasehigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاROS - ROSS-adenosylmethionine - اس-ادنوزیل متیونینstreptozotocin - استرپتوزوتوسینEndothelium - اندوتلیومBlood vessel - رگ خونیSOD - سدendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالSuperoxide dismutase - سوکسوکس دیسموتازcytochrome c oxidase - سیتوکروم سی اکسیدازcystathionine β-synthase - سیستاتیونین β-سنتازhypoxia-inducible factor-1 - فاکتور القای هیپوکسی -1Vascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Heart - قلب Low-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Methionine synthase - متیونین سنتازCopper - مسDietary reference intake - مصرف مرجع رژیم غذاییNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازhomocysteine - هوموسیستئینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
High blood copper (Cu) and homocysteine (Hcy) concentrations have been independently reported as risk factors for cardiovascular diseases. When they are simultaneously measured, a concomitant increase in both parameters in association with vascular dysfunction has been observed. Cu chelator penicillamine can significantly diminish the inhibitory effect of Hcy on endothelial function, which has led to the interpretation that Cu mediates the deleterious effect of Hcy. However, Cu itself has been shown to be beneficial to the cardiovascular system. In particular, Cu promotion of angiogenesis has been well documented. Cu stimulates endothelial cell proliferation and differentiation and promotes microtubule formation in cultured saphenous veins. High levels of Hcy do not affect the process of microtubule formation, but the combination of Cu and Hcy leads to a significant inhibitory effect. Under other conditions, Cu does not affect, but Hcy inhibits, the endothelium-dependent relaxation of blood vessels and the combination of both augments the inhibition. Why does Cu produce adverse effects when it co-exists with Hcy? Cu forms complexes with Hcy and the Cu-Hcy complexes possess a deleterious potential due to their redox properties. Cu chelation can remove Cu from the Cu-Hcy complexes, but leaves behind high levels of Hcy and produces Cu deficiency. An alternative approach should focus on the reduction of Hcy, but maintenance of Cu, making detrimental Cu beneficial. A comprehensive understanding of Cu speciation and a development of selective modulation of Cu coordination to Cu-binding molecules to avoid Cu-Hcy complex formation would effectively improve the condition of cardiovascular disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 129, Issue 3, March 2011, Pages 321-331
Journal: Pharmacology & Therapeutics - Volume 129, Issue 3, March 2011, Pages 321-331
نویسندگان
Y. James Kang,