کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844233 1561029 2016 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alcohol-induced dysregulation of stress-related circuitry: The search for novel targets and implications for interventions across the sexes
ترجمه فارسی عنوان
اختلال الکتریکی مدارهای مرتبط با استرس: جستجوی اهداف و پیامدهای جدید برای مداخلات در سراسر جنس
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
While the ability to process fermented fruits and alcohols was once an adaptive trait that improved nutrition and quality of life, the availability and prevalence of high potency alcoholic drinks has contributed to alcohol abuse disorders in a vulnerable portion of the population. Although the neural reward systems take part in the initial response to alcohol, negative reinforcement and stress, which are normally adaptive responses, can intersect to promote continued alcohol use at all stages of the addiction cycle. Eventually a point is reached where these once adaptive responses become dysregulated resulting in uncontrolled intake that constitutes a clinically important condition termed alcohol use disorder (AUD). Current research is targeted at both the behavioral and molecular adaptations in AUDs in an effort to better develop novel approaches to intervention. In this review, historical context is provided demonstrating the societal burden of alcohol use and abuse disorders. The importance of gender in the mechanism of action of alcohol is discussed. Finally, the impact of alcohol on stress-related circuitry, uncovered by preclinical research, is outlined to provide insight into potential novel pharmacological approaches to the treatment of AUD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 65, 4 February 2016, Pages 252-259
نویسندگان
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