Reduced antioxidant defense systems in schizophrenia and bipolar I disorder

► GSHt and GSHr levels were lower in both schizophrenic and bipolar I patients. ► Altered antioxidant enzymes were found in schizophrenia and bipolar I disorder. ► Oxidative stress could be involved in the physiopathology of these disorders. ► Glutathione could be an indirect biomarker of oxidative stress in these disorders.