Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE)

A series of monoquaternary pyridinium oximes having substituted aryl and aliphatic acetamido linkages as side chains were synthesized and evaluated for their in vitro reactivation efficacies against nerve agent (sarin, VX and tabun) inhibited human erythrocyte acetylcholinesterase (hAChE).