Synthesis, chemical identification, antioxidant capacities and immunological evaluation studies of a novel silver(I) carbocysteine complex

- One new carbocysteine complex was synthesized and characterized.
- SEM screening, thermal, EDX, 1H NMR, XRD and TG of this complex was investigated.
- The Ag+/Ccy possess the capacity to protect lung tissues and antioxidant enzymes from deleterious actions of Ccy alone.
- Ag+/Ccy increased the levels of SOD, GPX and decreased the level of MDA.
- The Ag+/Ccy complex has combined both the antioxidant capacities and immunological protective effects.

A new silver-carbocysteine (Ccy-Ag) complex [Ag2(Ccy)2(H2O)2] has been synthesized and characterized by using a combination of FTIR, Raman, molar conductivity, 1H NMR, electronic spectra, thermal analyses, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The infrared spectrum of Ccy-Ag complex in comparison with carbocysteine ligand prove that Ccy behaves as monobasic bidentate chelate to the silver metal ions via the deprotonated carboxylate O atom. The assessments of Ccy and its complexation with Ag+ in treating COPD, evaluating immune activities through measuring IL-8, TGF-β1, VEGF and TNF-α, antioxidant activities of (Ccy-Ag) complex by measuring SOD, MDA and GPX and bronchial asthma were discussed.

296