Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae

► Thirty four aryl methylcarbamates are examined for inhibition of AgAChE. ► Both WT and G119S carbamate-insensitive enzymes are examined. ► Recombinant enzyme results are compared to those from mosquito homogenates. ► We show that the 123 aa N-terminal domain of AgAChE does not affect inhibition. ► A predictive model for carbamate toxicity to Anopheles gambiae is presented.