Butyrylcholinesterase radioligands to image Alzheimer's disease brain

► Butyrylcholinesterase is found in regions of the brain important for cognition. ► In Alzheimer's disease, amyloid plaques are associated with butyrylcholinesterase. ► Enzyme trapping retains radiotracers in the brain for neuroimaging. ► Radioligands targeting butyrylcholinesterase detect Alzheimer's disease plaques. ► Butyrylcholinesterase is an important Alzheimer's disease diagnostic target.