کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856869 | 1131985 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insights from analysis for harmful and potentially harmful constituents (HPHCs) in tobacco products
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کلمات کلیدی
OCDDN-nitrosodiethylamineNDEAGlu-P-1N-nitrosonornicotineNNNHPHCAssay variabilityNNKNPYRNMORN-nitrosomorpholineNPIPTPMTrp-P-1FDAN-NitrosodiethanolaminenDMAN-nitrososarcosineN-nitrosomethylethylamine2-aminodipyrido[1,2-a:3′,2′-d]imidazoleLOQGlu-P-2OCDFN-nitrosopyrrolidineNMEATrp-P-2CDCMCsPhIP2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - 2-amino-1-methyl-6-phenylimidazo [4،5-b] pyridine2-amino-3-methyl-9H-pyrido[2,3-b]indole - 2-amino-3-methyl-9H-pyrido [2،3-b] indole2-amino-3-methylimidazo[4,5-f]quinoline - 2-amino-3-methylimidazo [4،5-f] quinoline2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole - 2-amino-6-methyldipyrido [1،2-a: 3 '، 2'-d] imidazole2-Amino-9H-pyrido[2,3-b]indole - 2-آمینو-9H-پیریدو [2،3-b] اندول2,3,7,8-TCDD - 2،3،7،8-TCDD2,3,7,8-Tetrachlorodibenzo-p-dioxin - 2،3،7،8-تترا کلریدیبنزوپتوفان دیوکسین3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole - 3-amino-1،4-dimethyl-5H-pyrido [4،3-b] indole4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone - 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanoneGC/MS - GC / MSGC/MS/MS - GC / MS / MSLC–MS/MS - LC-MS / MSN-Nitrosopiperidine - N-nitrosopiperidineN-nitrosodimethylamine - N-نیترزودیمتییلامینUS Food and Drug Administration - اداره غذا و داروی ایالات متحدهOctachlorodibenzo-p-dioxin - اکتاوکلودیبنزو-دی-دیوکسینISO - ایزوNSAR - بازارsmokeless tobacco - توتون بدون دودLOD یا Limit of detection - حد تشخیصMainstream cigarette smoke - دود سیگار اصلیtotal particulate matter - ذرات جامدNDELA - روشInternational Organization for Standardization - سازمان بین المللی استاندارد سازیCigarettes - سیگارinductively coupled plasma mass spectroscopy - طیف سنجی جرم پلاسما به صورت القاییgas chromatography–mass spectrometry - طیف سنجی جرم کروماتوگرافی گازICP-MS - طیفسنجی جرمی پلاسمای جفتشده القاییlimit of quantification - محدودیت اندازه گیریlimit of detection - محدودیت تشخیصCDC, Centers for Disease Control and Prevention - مراکز مدیریت و پیشگیری بیماریCooperation Centre for Scientific Research Relative to Tobacco - مرکز همکاری تحقیقات علمی مربوط به دخانیاتharmful and potentially harmful constituents - مواد مضر و بالقوه مضرHarmful and potentially harmful constituent - مواد مضر و مضرPAHs - هیدروکربن های آروماتیک چند حلقه ایPolyaromatic hydrocarbons - هیدروکربنهای Polyaromatichigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراCORESTA - کورستا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
A total of 20 commercial cigarette and 16 commercial smokeless tobacco products were assayed for 96 compounds listed as harmful and potentially harmful constituents (HPHCs) by the US Food and Drug Administration. For each product, a single lot was used for all testing. Both International Organization for Standardization and Health Canada smoking regimens were used for cigarette testing. For those HPHCs detected, measured levels were consistent with levels reported in the literature, however substantial assay variability (measured as average relative standard deviation) was found for most results. Using an abbreviated list of HPHCs, statistically significant differences for most of these HPHCs occurred when results were obtained 4-6Â months apart (i.e., temporal variability). The assay variability and temporal variability demonstrate the need for standardized analytical methods with defined repeatability and reproducibility for each HPHC using certified reference standards. Temporal variability also means that simple conventional comparisons, such as two-sample t-tests, are inappropriate for comparing products tested at different points in time from the same laboratory or from different laboratories. Until capable laboratories use standardized assays with established repeatability, reproducibility, and certified reference standards, the resulting HPHC data will be unreliable for product comparisons or other decision making in regulatory science.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 1, October 2014, Pages 138-148
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 1, October 2014, Pages 138-148
نویسندگان
Michael J. Oldham, Darren J. DeSoi, Lonnie T. Rimmer, Karl A. Wagner, Michael J. Morton,