کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857963 1562156 2016 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression
ترجمه فارسی عنوان
مونو-2-اتیل هگزیل فتالات باعث تخریب سلول های عصبی می شود و محیط زیست و تغییر ژن جنین را بیان می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Mono-2-ethylhexl phthalate (MEHP) is the primary metabolite of di-2-ethylhexyl phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how structural defects caused by MEHP in mouse whole embryo culture were related to temporal and spatial patterns of redox state and gene expression. MEHP reduced morphology scores along with increased incidence of neural tube defects. Glutathione (GSH) and cysteine (Cys) concentrations fluctuated spatially and temporally in embryo (EMB) and visceral yolk sac (VYS) across the 24 h culture. Redox potentials (Eh) for GSSG/GSH were increased by MEHP in EMB (12 h) but not in VYS. CySS/CyS Eh in EMB and VYS were significantly increased at 3 h and 24 h, respectively. Gene expression at 6 h showed that MEHP induced selective alterations in EMB and VYS for oxidative phosphorylation and energy metabolism pathways. Overall, MEHP affects neurulation, alters Eh, and spatially alters the expression of metabolic genes in the early organogenesis-stage mouse conceptus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 63, August 2016, Pages 32-48
نویسندگان
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