کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5861097 | 1562711 | 2016 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fusarium mycotoxin enniatin B: Cytotoxic effects and changes in gene expression profile
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کلمات کلیدی
FDRBEAIC50ED50Enniatinso/n - o / nenniatin - انیینتینGene expression - بیان ژنover night - بیش از شبBeauvericin - بیوریکینEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاRoom temperature - دمای اتاقIn vitro toxicity - سمیت درون in vitroFusarium - فوزاریم، فیوزاریم false discovery rate - میزان کشف کاذبMycotoxin - میوکوتوکسینEnn - نسبت بهETc - و غیره
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mycotoxin enniatin B, a cyclic hexadepsipeptide produced by the plant pathogen Fusarium, is prevalent in grains and grain-based products in different geographical areas. Although enniatins have not been associated with toxic outbreaks, they have caused toxicity in vitro in several cell lines. In this study, the cytotoxic effects of enniatin B were assessed in relation to cellular energy metabolism, cell proliferation, and the induction of apoptosis in Balb 3T3 and HepG2 cells. The mechanism of toxicity was examined by means of whole genome expression profiling of exposed rat primary hepatocytes. Enniatin B altered cellular energy metabolism and reduced cell proliferation in Balb 3T3 and HepG2 cell lines. Furthermore, the proportion of apoptotic cell populations of Balb 3T3 cells slightly increased. On the other hand, enniatin B caused necrotic cell death in primary hepatocytes. Gene expression studies revealed the alteration of energy metabolism due to effects on mitochondrial organization and function and the assembly of complex I of the electron transport chain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 34, August 2016, Pages 309-320
Journal: Toxicology in Vitro - Volume 34, August 2016, Pages 309-320
نویسندگان
Martina Jonsson, Marika Jestoi, Minna Anthoni, Annikki Welling, Iida Loivamaa, Ville Hallikainen, Matti Kankainen, Erik Lysøe, Pertti Koivisto, Kimmo Peltonen,