Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis

► Mechanisms of mitochondrial dysfunction during benzo[a]pyrene-induced apoptosis. ► GSK3α controls B[a]P-induced c-Myc down-regulation. ► c-Myc down-regulation regulates mitochondrial localization of Hexokinase II. ► These events are involved in B[a]P-induced intrinsic apoptosis.