کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904629 | 1158039 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Kt/V ureaEPAFGF-23pTH1,25(OH)2D - 1،25 (OH) 2D1,25-dihydroxyvitamin D - 1،25-دی هیدروکسوییتامین D25(OH)D - 25 (OH) D25-hydroxyvitamin D - 25 هیدروکسی ویتامین DArachidonic acid - اسید آراشیدونیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکFatty acid - اسید چربOmega-3 fatty acid - اسید چرب امگا 3Human - انسانcardiovascular disease - بیماری قلب و عروقیBUN - خوبDHA - دوکوساهگزائنوئیک اسیدDialysis - دیالیزPeritoneal dialysis - دیالیز صفاقیCVD - رسوب دهی شیمیایی بخار body mass index - شاخص توده بدنBMI - شاخص توده بدنیfibroblast growth factor 23 - فاکتور رشد فیبروبلاست 23Fetuin-A - فتویین Ablood urea nitrogen - نیتروژن اوره خونHemodialysis - همودیالیزparathyroid hormone - هورمون پاراتیروئیدC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Vascular calcification - کلسیفیکاسیون عروقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vitamin D deficiency, low levels of fetuin-A, and fibroblast growth factor 23 (FGF-23) are related to vascular calcification, which is associated with cardiovascular disease. We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. In a randomized, open-label, controlled study, a total of 47 patients treated with dialysis for at least 1 year were randomized to treatment for 6 months with omega-3 FAs (Omacor, 3 g/d; Pronova, Sandefjord, Norway) or a control group. Levels of fetuin-A and FGF-23 were measured by enzyme-linked immunoassay, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured by radioimmunoassay. The mean age of the enrolled patients was 57.4 ± 10.4 years, and mean dialysis duration was 46.5 ± 28.1 months. Twenty-seven hemodialysis patients and 16 peritoneal dialysis patients finished this trial. After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Levels of calcium, phosphorous, parathyroid hormone, 25-hydroxyvitamin D, FGF-23, and lipid profiles were not significantly changed in the omega-3 FA-supplemented group after 6 months compared with baseline. The erythrocyte membrane contents of eicosapentaenoic acid and docosahexaenoic acid were significantly increased, and oleic acid content was significantly decreased in the omega-3 FA-supplemented group after 6 months compared with baseline. Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 32, Issue 7, July 2012, Pages 495-502
Journal: Nutrition Research - Volume 32, Issue 7, July 2012, Pages 495-502
نویسندگان
Won Suk An, Su Mi Lee, Young Ki Son, Seong Eun Kim, Ki Hyun Kim, Jin Yeong Han, Hae Rahn Bae, Seo Hee Rha, Yongsoon Park,