کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022290 1580670 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nogo and Nogo receptor: Relevance to schizophrenia?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Nogo and Nogo receptor: Relevance to schizophrenia?
چکیده انگلیسی
The membrane protein Nogo-A and its receptor NgR have been extensively characterized for their role in restricting axonal growth, regeneration, and plasticity in the central nervous system. Recent evidence suggests that Nogo and NgR might constitute candidate genes for schizophrenia susceptibility. In this article, we critically review the possibility that dysfunctions related to Nogo-A and NgR might contribute to increased risk for schizophrenia. To this end, we consider the most important insights that have emerged from human genetic and pathological studies and from experimental animal work. Furthermore, we discuss potential mechanisms of Nogo/NgR involvement in neural circuit development and stability, and how mutations or changes in expression levels of these proteins could be developmental risk factors contributing to schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 54, June 2013, Pages 150-157
نویسندگان
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