Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity

► Infarct volumes and behavioral deficits were reduced in FP antagonist AL8810 mice. ► Similar results in FP knockout mice after permanent ischemic stroke. ► FP receptor blockade protects against oxygen glucose deprivation cell death in organotypic slices. ► Neuronal death is less in cells treated with AL8810 not in cultured astrocytes. ► FP receptor agonist increases intracellular calcium levels of cultured neurons.