کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6062605 | 1201842 | 2016 | 14 صفحه PDF | دانلود رایگان |

BackgroundTranscutaneous exposure to food allergens can lead to food sensitization (FS)/food allergy (FA). We measured skin barrier function in early infancy and related it to the later development of FS/FA at age 2Â years.ObjectiveWe sought to examine the relationship between early life skin barrier function and FA in infancy.MethodsInfants in the Babies After Scope: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) birth cohort had transepidermal water loss (TEWL) measured in the early newborn period and at 2 and 6Â months of age. At age 2Â years, infants had FS/FA screening with skin prick tests and oral food challenges.ResultsOne thousand nine hundred three infants were enrolled. One thousand three hundred fifty-five were retained to age 2Â years, and 1260 underwent FS screening. FS was present in 6.27% (79/1260; 95% CI, 4.93% to 7.61%), and FA prevalence was 4.45% (56/1258; 95% CI, 3.38% to 5.74%). Egg was the most prevalent allergen (2.94%), followed by peanut (1.75%) and cow's milk (0.74%). Day 2 upper-quartile TEWL (>9 gwater/m2/h) was a significant predictor of FA at age 2Â years (odds ratio [OR], 4.1; 95% CI, 1.5-4.8). Seventy-five percent of children with FA at 2Â years of age had day 2 TEWL in the upper quartile. Even in those without atopic dermatitis (AD), infants with upper-quartile day 2 TEWL were 3.5 times more likely to have FA at 2Â years than infants in the lowest quartile (95% CI, 1.3-11.1; PÂ =Â .04).ConclusionNeonatal skin barrier dysfunction predicts FA at 2Â years of age, supporting the concept of transcutaneous allergen sensitization, even in infants who do not have AD. TEWL could be used for stratifying infants in the first few days of life before development of AD or FA for targeted intervention studies to potentially alter the atopic march.
Journal: Journal of Allergy and Clinical Immunology - Volume 137, Issue 4, April 2016, Pages 1111-1116.e8