A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa

Our results suggest that TSLP-mediated activation of human nasal mucosal CD1c+ DCs triggers CCR7-dependent migration to the draining lymph nodes and enhances their capacity to initiate TH2 responses. However, the observation that TH2 cytokines abrogate the induction of CCR7 implies that during a TH2-mediated inflammatory reaction, TLSP-activated CD1c+ DCs are retained in the inflamed tissue to further exacerbate local inflammation by activating local antigen-specific memory TH2 cells.