کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6066220 1201883 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Food, drug, insect sting allergy, and anaphylaxisPlatelet-activating factor, histamine, and tryptase levels in human anaphylaxis
ترجمه فارسی عنوان
غذا، دارو، آلرژی زخم حشرات، و آنافیلاکسی، فاکتور فعال کننده پلاکت، هیستامین و ترپتاسین در آنافیلاکسی انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

BackgroundPlatelet-activating factor (PAF) is an important mediator and correlates with anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase is not known.ObjectiveTo analyze the levels of PAF, histamine, and tryptase as a function of severity in patients with acute allergic reactions.MethodsPAF, histamine, and tryptase levels were measured in blood samples collected from 23 healthy volunteers and from 41 patients during acute allergic reactions. Reactions were stratified by severity from grade 1 (least severe) to grade 3 (most severe).ResultsAmong the 3 reaction grades, there were significant differences by ANOVA for PAF (P < .0001). The proportion of elevated PAF values increased across severity groups (P = .0009). Increased PAF levels were observed in 20%, 66.7%, and 100% of the patients with grades 1, 2, and 3 allergic reactions, respectively. While the proportion of elevated histamine values increased from 40% to 57% to 70% across grades 1, 2, and 3, respectively, these were not significantly different (P = .40). For tryptase, the proportion of elevated values increased monotonically from 0 in grade 1 to 4.8% in grade 2 to 60% in grade 3 (P = .0002).ConclusionsThe PAF level was significantly elevated in proportion to the severity of acute allergic reactions. Whereas the PAF level was elevated in all patients with severe anaphylaxis, this was not true for either histamine or tryptase. Neither histamine nor tryptase showed as good correlations with severity scores as did PAF. These data are consistent with a pivotal role for PAF as a mediator of anaphylaxis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 131, Issue 1, January 2013, Pages 144-149
نویسندگان
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