کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6071013 1587515 2015 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articlePrognostic factors in necrotizing soft-tissue infections (NSTI): A cohort study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Original articlePrognostic factors in necrotizing soft-tissue infections (NSTI): A cohort study
چکیده انگلیسی

BackgroundNecrotizing soft-tissue infection (NSTI) is uncommon but life-threatening. A recent meta-analysis estimated the overall mortality at 23.5%.ObjectiveWe sought to identify risk factors associated with mortality in a cohort of patients with NSTI in a tertiary care center.MethodsWe identified 512 patients with NSTI between 1996 and 2012 in the national hospital database Program for Medicalization of Information Systems and examined risk factors of mortality with NSTI by univariate and multivariate analysis.ResultsWe included 109 patients with a confirmed diagnosis of NSTI; 31 (28%) died at a median follow-up of 274 days (range 2-6135 days). On multivariate analysis, independent risk factors of mortality were age older than 75 years (hazard ratio [HR] 4.4, 95% confidence interval [CI] 1.8-10.3), multifocal NSTI (HR 5.9, 95% CI 1.9-18.5), severe peripheral vascular disease (HR 5.1, 95% CI 1.5-17.0), hospital-acquired infection (HR 3.9, 95% CI 1.4-10.7), severe sepsis (HR 7.4, 95% CI 1.7-33.1), and septic shock on hospital admission (HR 13.9, 95% CI 3.8-50.4).LimitationsThis was a retrospective cohort, which disallows a precise record of the delay between diagnosis and surgery.ConclusionOur findings for this robust cohort of patients with a definite diagnosis of NSTI could help clinicians stratify NSTI severity at clinical course onset.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 73, Issue 6, December 2015, Pages 1006-1012.e8
نویسندگان
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