کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6073291 | 1587541 | 2014 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)
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کلمات کلیدی
PD-1large cell transformationTCrLCTISCLCLAGMFCTCLAPCTregHTLV-1emf - EMFcutaneous lymphocyte antigen - آنتی ژن لنفوسیت پوستیantigen-presenting cell - آنتیژن ارائه سلولGenetic aberrations - اختلالات ژنتیکیprognostic value - ارزش پیش آگهیinterleukin - اینترلوکینRegulatory T cells - سلولهای تی تنظیمکنندهSézary syndrome - سندرم سزاریMycosis fungoides - قارچ MycosisCutaneous T-cell lymphoma - لنفوم پوستی TTumor microenvironment - میکرو محیط زیست تومورHistopathology - هیستوپاتولوژیHuman T-lymphotropic virus type 1 - ویروس T-lymphotropic انسانی نوع 1Pathogenesis - پاتونزT-cell receptor - گیرنده لنفوسیت T
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mycosis fungoides (MF) and Sézary syndrome (SS) comprise approximately 53% of cutaneous lymphomas. Both MF and SS may clinically and histologically mimic benign skin conditions, posing a diagnostic challenge to the dermatologist. Precise clinicopathologic correlation is necessary to support a diagnosis, especially in the early stages of disease. In addition to the identification of histopathologic criteria, ancillary studies, including the identification of CD4+ T cells with aberrant immunophenotypes and T-cell receptor gene rearrangements within skin lesions and peripheral blood are used to support the diagnosis. Recent studies evaluating the pathogenesis of MF have found that the skin microenvironment, including immune cells, such as dendritic cells and reactive cytotoxic and regulatory T cells, plays a crucial supporting role in MF. The skin-homing ability of malignant T cells is the result of chemokines, cytokines, adhesion molecules, and defective apoptosis, and is believed to play a role in disease pathogenesis and progression. In addition, recent studies have also suggested that MF and SS arise from distinct memory TÂ cell subsets and advanced/erythrodermic MF and SS may be distinguished by identification of certain molecules, including Programmed-Death-1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 70, Issue 2, February 2014, Pages 205.e1-205.e16
Journal: Journal of the American Academy of Dermatology - Volume 70, Issue 2, February 2014, Pages 205.e1-205.e16
نویسندگان
Sarah I. BA, Patricia L. MD, Steven MD, Alison MD, Christiane MD, PhD,