کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074430 | 1203485 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epigenome-Wide Association Analysis Identified Nine Skin DNA Methylation Loci for Psoriasis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and environmental factors. DNA methylation has been linked to psoriasis, but the manner in which this process contributes to the disease is not fully understood. In this study, we carried out a three-stage epigenome-wide association study to identify disease-associated differentially methylated sites using a combination of 262 skin and 48 peripheral blood mononuclear cell samples. We not only revealed genome-wide methylation patterns for psoriasis but also identified strong associations between the skin-specific DNA methylation of nine disease-associated differentially methylated sites and psoriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10). Further analysis revealed that these nine disease-associated differentially methylated sites were not significantly affected by genetic variations, supporting their remarkable contributions to disease status. The expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 was negatively correlated with DNA methylation. These findings will help us to better understand the molecular mechanism of psoriasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 4, April 2016, Pages 779-787
Journal: Journal of Investigative Dermatology - Volume 136, Issue 4, April 2016, Pages 779-787
نویسندگان
Fusheng Zhou, Wenjun Wang, Changbing Shen, Hui Li, Xianbo Zuo, Xiaodong Zheng, Min Yue, Cuicui Zhang, Liang Yu, Mengyun Chen, Caihong Zhu, Xianyong Yin, Mingjun Tang, Yongjiang Li, Gang Chen, Zaixing Wang, Shengxiu Liu, Yi Zhou, Xuejun Zhang,