کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074773 | 1203488 | 2016 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk of Multiple Sclerosis in Patients with Psoriasis: A Danish Nationwide Cohort Study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
IRRATCSKSTNFICD - دفیبریلاتورهای کاردیوورتر کاشتنیAnatomical Therapeutic Chemical - شیمی درمانی آناتومیInternational Classification of Diseases - طبقه بندی بین المللی بیماری هاconfidence interval - فاصله اطمینانtumor necrosis factor - فاکتور نکروز تومورMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)Incidence rate - نرخ بروزincidence rate ratio - نسبت میزان بروز
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Psoriasis and multiple sclerosis (MS) are inflammatory disorders with similarities in genetic risk variants and inflammatory pathways. Limited evidence is available on the relationship between the two diseases. We therefore investigated the risk of incident (new-onset) MS in patients with mild and severe psoriasis, respectively. All Danish citizens aged ⥠18 years from 1 January 1997 to 31 December 2011 were identified by linkage of nationwide registries at the individual level. We estimated incidence rate ratios (IRRs) adjusted for age, gender, socioeconomic status, smoking, medication, comorbidity, and UV phototherapy by Poisson regression. There were 58,628 and 9,952 cases of mild and severe psoriasis, respectively, and 9,713 cases of MS. Incidence rates of MS per 10,000 person-years for the reference population, mild psoriasis, and severe psoriasis were 1.78, 3.22, and 4.55, respectively. Adjusted IRRs of MS were 1.84 (95% confidence interval [CI], 1.46-2.30) and 2.61 (95% CI, 1.44-4.74) in mild and severe psoriasis, respectively. Similar results were observed when adjustment for family history of MS was included in the analyses. Psoriasis may confer a disease severity-dependent risk of MS. Further studies are warranted to establish the mechanisms underlying this relationship and its potential clinical consequences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 93-98
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 93-98
نویسندگان
Alexander Egeberg, Lotus Mallbris, Gunnar Hilmar Gislason, Lone Skov, Peter Riis Hansen,