کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074865 | 1203489 | 2016 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cartilage Oligomeric Matrix Protein Increases in Photodamaged Skin
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کلمات کلیدی
ECMPBSTGFCOMPTGFBR2NHDFBSA - BSAbovine serum albumin - آلبومین سرم گاوUltraviolet - اشعه فرابنفشtransforming growth factor - تبدیل فاکتور رشدNormal human dermal fibroblast - فیبروبلاست طبیعی پوستی انسانExtracellular matrix - ماتریکس خارج سلولیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریCartilage oligomeric matrix protein - پروتئین ماتریکس oligomeric غضروفیTGF-β type II receptor - گیرنده TGF-β نوع II
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage. Recent studies have described COMP as a pathogenic factor that promotes collagen deposition in fibrotic skin disorders such as scleroderma and keloid skin. Although collagen, a major dermis component, is thought to decrease in photoaged skin, recent reports have demonstrated the presence of tightly packed collagen fibrils with a structural resemblance to fibrosis in the papillary dermis of photoaged skin. Here we examined how photoaging damage relates to COMP expression and localization in photoaged skin. In situ hybridization revealed an increase in COMP-mRNA-positive cells with the progress of photoaging in preauricular skin (sun-exposed skin). The signal intensity of immunostaining for COMP increased with photoaging in not only the papillary dermis but also the reticular dermis affected by advancing solar elastosis. Immunoelectron microscopy detected the colocalization of COMP with both elastotic materials and collagen fibrils in photoaged skin. Ultraviolet light A irradiation of human dermal fibroblasts induced COMP expression at both the mRNA and protein levels. Ultraviolet light A-induced COMP expression was inhibited by an anti-transforming growth factor-β antibody or SB431542, an activin receptor-like kinase 5 inhibitor. These results suggest that the transforming growth factor-β-mediated upregulation of COMP expression may contribute to the modulation of dermal extracellular matrix in the photoaging process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 6, June 2016, Pages 1143-1149
Journal: Journal of Investigative Dermatology - Volume 136, Issue 6, June 2016, Pages 1143-1149
نویسندگان
Masaki Kobayashi, Keigo Kawabata, Ayumi Kusaka-Kikushima, Yoshinori Sugiyama, Tomotaka Mabuchi, Susumu Takekoshi, Muneo Miyasaka, Akira Ozawa, Shingo Sakai,