کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074870 | 1203489 | 2016 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Longitudinal Evaluation of the Skin Microbiome and Association with Microenvironment and Treatment in Canine Atopic Dermatitis
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کلمات کلیدی
ANOSIMTEWLrRNADNA - DNA یا اسید دزوکسی ریبونوکلئیکTransepidermal water loss - از دست دادن آب دریچهdeoxyribonucleic acid - اسید deoxyribonucleicribosomal ribonucleic acid - اسید ریبونوکلئیک ریبوزومیanalysis of similarity - تجزیه و تحلیل شباهتAtopic dermatitis - درماتیت آتوپیکcanine atopic dermatitis - درماتیت آتوپیک سگCAD - طراحی به کمک رایانه یا کَد
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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![عکس صفحه اول مقاله: Longitudinal Evaluation of the Skin Microbiome and Association with Microenvironment and Treatment in Canine Atopic Dermatitis Longitudinal Evaluation of the Skin Microbiome and Association with Microenvironment and Treatment in Canine Atopic Dermatitis](/preview/png/6074870.png)
چکیده انگلیسی
Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization with Staphylococcus species. To examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous model of canine atopic dermatitis. In a cohort of 14 dogs with canine atopic dermatitis, the skin microbiota were longitudinally evaluated with parallel assessment of skin barrier function at disease flare, during antimicrobial therapy, and post-therapy. Sequencing of the bacterial 16S ribosomal RNA gene showed decreased bacterial diversity and increased proportions of Staphylococcus (S. pseudintermedius in particular) and Corynebacterium species compared with a cohort of healthy control dogs (n = 16). Treatment restored bacterial diversity with decreased proportions of Staphylococcus species, concurrent with decreased canine atopic dermatitis severity. Skin barrier function, as measured by corneometry, pH, and transepidermal water loss also normalized with treatment. Bacterial diversity correlated with transepidermal water loss and pH level but not with corneometry results. These findings provide insights into the relationship between the cutaneous microbiome and skin barrier function in atopic dermatitis, show the impact of antimicrobial therapy on the skin microbiome, and highlight the utility of canine atopic dermatitis as a spontaneous nonrodent model of atopic dermatitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 6, June 2016, Pages 1182-1190
Journal: Journal of Investigative Dermatology - Volume 136, Issue 6, June 2016, Pages 1182-1190
نویسندگان
Charles W. Bradley, Daniel O. Morris, Shelley C. Rankin, Christine L. Cain, Ana M. Misic, Timothy Houser, Elizabeth A. Mauldin, Elizabeth A. Grice,