کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6075049 | 1203492 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production
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کلمات کلیدی
mRNACHSMMP-12FPKMDNFBqPCRSOCS32,4-dinitrofluorobenzene - 2،4-دینیتروفلووروبنزنmessenger RNA - RNA messengerContact hypersensitivity - تماس با افزایش حساسیتTIMP - زمانsuppressor of cytokine signaling-3 - سرکوبگر سیگنالینگ سیتوکین-3Matrix metalloproteinase-12 - ماتریکس متالوپروتئیناز-12bone marrow - مغز استخوانTissue inhibitor of metalloproteinase - مهار کننده های متالوپروتئیناز بافتquantitative real-time PCR - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیMannose receptor - گیرنده مانوز
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Numerous studies have clarified the immunological mechanisms of contact hypersensitivity (CHS). In addition, we have recently shown that M2 macrophages play key roles in the development of CHS by producing matrix metalloproteinase-12 (MMP-12). However, regulatory mechanisms of the elicitation phase in CHS remain largely unknown. To determine the roles of suppressor of cytokine signaling (SOCS) family members in M2 macrophages in the regulation of CHS, we investigated the expression of SOCS family members in M2 macrophages at the inflammatory sites of CHS. Transcriptome analysis revealed that among SOCS family members, SOCS3 was highly expressed in M2 macrophages at the site of CHS, and SOCS3 induction was reduced by IFN-γ neutralization. 2,4-Dinitrofluorobenzene-induced CHS was significantly enhanced and prolonged in mice lacking SOCS3 expression in monocytes/macrophages (SOCS3Î/Î mice) compared with that in control mice. Importantly, expression of MMP-12 in M2 macrophages was significantly increased in SOCS3Î/Î mice at the site of CHS, and deletion of the MMP-12 gene reduced the exacerbated CHS in SOCS3Î/Î mice. Finally, IFN-γ inhibited IL-4-induced MMP-12 expression in a SOCS3-dependent manner. Taken together, these results suggest that SOCS3 expressed in M2 macrophages is involved in the attenuation and/or resolution of CHS, presumably by suppressing MMP-12 production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 3, March 2016, Pages 649-657
Journal: Journal of Investigative Dermatology - Volume 136, Issue 3, March 2016, Pages 649-657
نویسندگان
Kazuyuki Meguro, Daiki Nakagomi, Kotaro Suzuki, Junichi Hosokawa, Tadashi Fukuta, Masaya Yokota, Yuko Maezawa, Akira Suto, Hiroshi Nakajima,