کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125894 | 1221036 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis
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کلمات کلیدی
DLNBALTLRGM-CSFTregMTBSIVT helperTIMTGFESAT-6phthiocerol dimycocerosatePGLMVA85APDIMTNFMucosal-associated invariant TPAMPsBCGTCrHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیpathogen-associated molecular patterns - الگوهای مولکولی مرتبط با پاتوژنinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینBacille de Calmette et Guérin - باسی کالمت و گورینTuberculosis - بیماری سلtransforming growth factor - تبدیل فاکتور رشدToll-like receptor - تیالآرLung - ریهRegulatory T cell - سلول T تنظیم کنندهT cell - سلول تیDendritic cell - سلول دندریتیکgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factortumor necrosis factor - فاکتور نکروز تومورListeria monocytogenes - لیستریا مونوسیتوژنزMycobacterium tuberculosis - مایکوباکتریوم توبرکلوزیسRegulation - مقرراتMAIT - مهمانVaccine - واکسنhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی Simian immunodeficiency virus - ویروس کمبود ایمنی سیمانیDraining lymph node - گره لنفاوی تخلیهT cell receptor - گیرنده سلول T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary mediators of adaptive immunity against TB. Unfortunately, the onset of the T cell response after aerosol infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes TB, is exceedingly slow, and systemically administered vaccines only modestly accelerate the recruitment of effector T cells to the lungs. This delay seems to be orchestrated by Mtb itself to prolong the period of unrestricted bacterial replication in the lung that characterizes the innate phase of the response. When T cells finally arrive at the site of infection, multiple layers of regulation have been established that limit the ability of T cells to control or eradicate Mtb. From this understanding, emerges a strategy for achieving immunity. Lung resident memory T cells may recognize Mtb-infected cells shortly after infection and confer protection before regulatory networks are allowed to develop. Early studies using vaccines that elicit lung resident T cells by targeting the lung mucosa have been promising, but many questions remain. Due to the fundamental nature of these questions, and the need to understand and manipulate the early events in the lung after aerosol infection, only coordinated approaches that utilize tractable animal models to inform human TB vaccine trials will move the field toward its goal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 26, Issue 6, December 2014, Pages 578-587
Journal: Seminars in Immunology - Volume 26, Issue 6, December 2014, Pages 578-587
نویسندگان
Kevin B. Urdahl,