کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6136113 | 1224973 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The essential role of IFN-γ in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice
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کلمات کلیدی
iNOSIFN-γAggregatibacter actinomycetemcomitansT helper lymphocyteMPO - DFOPeriodontal diseases - بیماری های پریودنتالPeriodontal disease - بیماری پریودنتال یا پیرادندانیinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییmyeloperoxidase - میلوپراکسیداز Nitric oxide - نیتریک اکسیدpost-infection - پس از عفونت
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The essential role of IFN-γ in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice The essential role of IFN-γ in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice](/preview/png/6136113.png)
چکیده انگلیسی
Inflammatory immune reactions in response to periodontopathogens trigger periodontal destruction, but their role to protect the host against infection remains unknown. Thus, we examined the mechanisms by which IFN-γ modulates the outcome of Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice. Our results showed that IFN-γ deficient mice developed less severe periodontitis in response to A. actinomycetemcomitans infection, characterized by significant lower alveolar bone loss and inflammatory reaction. However, the absence of IFN-γ results in increased bacterial load in periodontal tissues and higher acute phase reaction, followed by a disseminated bacterial infection and mice death during the course of the disease. Such impaired host response was found to be associated with a reduction in the levels of inflammatory cytokines and chemokines and in the number of GR1+, F4/80+, CD4+ and CD8+ leukocytes in the diseased periodontium of IFN-γ deficient mice. In addition, the levels of both antimicrobial mediators myeloperoxidase and inducible nitric oxide synthase were also found to be reduced in IFN-KO mice. Our results demonstrate for the first time that a periodontal infection may be lethal in an immunocompromised host. In addition, the mechanisms involved in IFN-γ mediated cell migration to diseased periodontal tissues, and its essential role to control A. actinomycetemcomitans infection were clarified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 10, Issue 5, April 2008, Pages 489-496
Journal: Microbes and Infection - Volume 10, Issue 5, April 2008, Pages 489-496
نویسندگان
Gustavo P. Garlet, Cristina R.B. Cardoso, Ana P. Campanelli, Thiago P. Garlet, Mario J. Avila-Campos, Fernando Q. Cunha, João S. Silva,