کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6228145 1276502 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?
چکیده انگلیسی

BackgroundSubjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses.MethodsTo investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects.ResultsWe observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin.ConclusionsThis finding provides support for further investigations of the theory of abnormal functioning of this hormonal system in autism and potentially for experimental therapeutic approaches with oxytocin and related neuropeptides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 70, Issue 3, 1 August 2011, Pages 278-282
نویسندگان
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