کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6308781 | 1618859 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner
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کلمات کلیدی
FSHR17βHSDlhβGnRHCytochrome p450 side-chain cleavageFSHβ3βHSDCYP19cytochrome P450 17CYP11A11-KTLHR17β-Hydroxysteroid dehydrogenase3β-Hydroxysteroid dehydrogenaseGnRHRHPGCYP17Vitellogenin11-ketotestosterone - 11-کتواستاسترون17β-estradiol - 17β استرادیولRare minnow (Gobiocypris rarus) - Minnow نادر (Gobiocypris rarus)Endocrine disruption - اختلالات غدد درون ریزBenzotriazole - بنزوتریازولStar - ستارهGonadotropin-releasing hormone - هورمون آزاد کننده گنادوتروپینSteroid hormone - هورمون استروئیدHistopathology - هیستوپاتولوژیhypothalamic–pituitary–gonadal - هیپوتالاموس-هیپوفیز-گنادالvtg - ویتگSteroidogenic acute regulatory protein - پروتئین حاکم استروئیدوژنیک حادAndrogen Receptor - گیرنده آندروژنیEstrogen receptor - گیرنده استروژنgonadotropin-releasing hormone receptor - گیرنده هورمون آزاد کننده گنادوتروپینFollicle stimulating hormone receptor - گیرنده هورمون تحریک کننده فولیکولLuteinizing hormone receptor - گیرنده هورمون لوتئینیزاسیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Benzotriazole (BT), an anticorrosive agent, is widely used in industrial applications and household dishwashing agents. Despite its reported toxicity to aquatic organisms, little is known about its endocrine disrupting effects. In this study, adult Chinese rare minnows (Gobiocypris rarus) were exposed to 0.05, 0.5, and 5 mg Lâ1 BT for 28 d. The pathological damage in liver was associated with hypertrophy of the hepatocytes, nuclei pyknosis and vacuolization at 5 mg Lâ1 groups. Additionally, the degeneration of the ovary and the stimulation of spermatogenesis were observed at 5 mg Lâ1 groups. The plasma 17β-estradiol level was significantly increased in the males but decreased in the females at 5 mg Lâ1 (p < 0.05). In the brain, the up-regulation of CYP19B, GnRHs, and LHβ mRNA was detected across all doses (p < 0.05). In the gonad, the transcriptional levels of StAR, CYP11A, 3βHSD, CYP17, 17βHSD, and CYP19A were generally decreased in the males at 5 mg Lâ1 (p < 0.05), whereas these genes, except for 3βHSD, were significantly increased in females at all concentrations (p < 0.05). Moreover, the expression level of VTG in the livers from all exposure groups was significantly increased compared with controls (p < 0.05). Taken together, our results indicate that BT could adversely affect the rare minnows in a sex-dependent manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 112, October 2014, Pages 154-162
Journal: Chemosphere - Volume 112, October 2014, Pages 154-162
نویسندگان
Xuefang Liang, Miao Wang, Xi Chen, Jinmiao Zha, Huihui Chen, Lifei Zhu, Zijian Wang,