کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6308985 | 1618857 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of persistent organic pollutants on oxidative stress in population-based samples
ترجمه فارسی عنوان
تأثیر آلاینده های آلی پایدار بر استرس اکسیداتیو در نمونه های مبتنی بر جمعیت
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کلمات کلیدی
GSHOCDDTEQTEFGSSGPIVUSPCBstGSHBDEGSSG/GSHQA/QC - QA / QCROS - ROSPOPs - آلایندههای آلی دیرپاPersistent organic pollutants - آلایندههای آلی دیرپا(پایدار)Organochlorine - ارگانوکلرینProspective Investigation of the Vasculature in Uppsala Seniors - بررسی آیندهی عروق در روانپزشکان اوپسالاPolychlorinated biphenyls - بیفنیل پلیکلر Quality assurance/quality control - تضمین کیفیت / کنترل کیفیتLOD یا Limit of detection - حد تشخیصconjugated dienes - دین های کنجوج شدهCoefficient of Variation - ضریب تغییرToxic equivalency factors - عوامل همسان سازی سمیLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)limit of detection - محدودیت تشخیصreduced glutathione - کاهش گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شدهtotal glutathione - گلوتاتیون کلReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Persistent organic pollutants (POPs) are a large group of chemicals widely used and produced in various industrial applications. Many cell culture/animal studies have shown that POPs can induce oxidative stress. Since such data is lacking in humans, we conducted a large population-based study to analyze associations between POPs and oxidative stress markers. We measured following POPs; 16 polychlorinated biphenyls (PCBs), 5 organochlorine (OC) pesticides, octachlorinated dibenzo-p-dioxin, and polybrominated diphenyl ether 47, and oxidative stress markers; homocysteine, reduced [GSH] and oxidized glutathione [GSSG], glutathione ratio [GSSG/GSH], total glutathione, oxidized low-density lipoprotein [ox-LDL], ox-LDL antibodies, conjugated dienes, baseline conjugated dienes of LDL, and total anti-oxidative capacity in plasma samples collected from 992 70-year old individuals (50% women) from the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Linear regression analyses were performed to study the associations between oxidative stress markers and summary measures of POPs including the total toxic equivalence (TEQ), sums of PCBs and OC pesticides (main exposures) while adjusting for potential confounders. In multivariable-adjusted analyses, sum of PCBs showed strong associations with ox-LDL (β = 0.94; P = 2.9 * 10â6). Further, sum of PCBs showed association with glutathione-related markers (GSSG: β = â0.01; P = 6.0 * 10â7; GSSG/GSH: β = â0.002; P = 9.7 * 10â10), although in reverse direction. Other summary measures did not show any significant association with these markers. In our study of elderly individuals from the general population, we show that plasma levels of POPs are associated with markers of increased oxidative stress thereby suggesting that even low dose background exposure to POPs may be involved in oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 114, November 2014, Pages 303-309
Journal: Chemosphere - Volume 114, November 2014, Pages 303-309
نویسندگان
Jitender Kumar, P. Monica Lind, Samira Salihovic, Bert van Bavel, Lars Lind, Erik Ingelsson,