کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6350897 | 1622551 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exposure to mercury in susceptible population groups living in the former mercury mining town of Idrija, Slovenia
ترجمه فارسی عنوان
قرار گرفتن در معرض جیوه در گروه های حساس جمعیت که در شهر معدن جیوه معدنی ایبریا اسلوونی زندگی می کنند
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کلمات کلیدی
P90P10MAXCATGPXRfDHg2+ - Hg2 +THg - THGAntioxidative enzymes - آنزیم های آنتی اکسیداتیوstandard deviation - انحراف معیارMaximum - بیشترینSusceptible population - جمعیت قابل قبولElemental mercury - جیوه عنصریInorganic mercury - جیوه معدنیMin - حداقلReference dose - دوز مرجعSOD - سدSelenium - سلنیومSuperoxide dismutase - سوکسوکس دیسموتازCoefficient of Variation - ضریب تغییرconfidence interval - فاصله اطمینانMercury exposure - قرار گرفتن در معرض جیوهGeometric mean - میانگین هندسیhaemoglobin - هموگلوبینCatalase - کاتالازTotal mercury - کل جیوهMinimum - کمترینglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
500 years of mercury (Hg) mining in the town of Idrija has caused severe pollution in Idrija and its surroundings. Following the closure of the mine in 1995, the environment remains contaminated with Hg. Sources of elemental-, inorganic- and methyl Hg exposure were identified, potential environmental level of exposure to Hg was evaluated and actual internal exposure to Hg was assessed in selected susceptible population groups comprising school-age children and pregnant women living in Idrija and in control groups from rural and urban environments. The study of pregnant women (n=31) was conducted between 2003 and 2008, and the study of school-age children (n=176) in 2008. Potential interaction of Hg with selenium (Se) in plasma was assessed in both study populations, while in pregnant women antioxidative enzyme activity (glutathione peroxidase, superoxide dismutase and catalase) in erythrocytes of maternal and cord blood was also assessed. Actual exposure to Hg as indicated by levels of Hg in children's blood (geometric mean (GM) 0.92 µg/L), mother's blood (GM 1.86 µg/L), children's urine (GM 1.08 µg/g crea.), mother's urine (GM 2.51 µg/L), children's hair (GM 241 ng/g) and mother's hair (GM 251 ng/g) was higher in the two study groups from Idrija than in the control groups from rural areas, but was still at the level of a “normal” population and reflects mainly exposure to elemental Hg (Hg°) from dental amalgam and, to a certain extent atmospheric Hg°. Furthermore, the internal doses of Hg received during pregnancy did not decrease the bioavailability of Se. Based on observation in children, the increase in Se protein expression is suggested to be a consequence of moderately elevated exposure to Hg°. The observed changes in activity of antioxidative enzymes, as biomarkers of oxidative stress, appear to be mainly associated with pregnancy per se and not with an increased exposure to Hg. In view of the continuing increased potential for Hg exposure and the low number of pregnant women studied, the results warrant a further longitudinal study of a larger group of pregnant women residing in the area of the former mercury mine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 152, January 2017, Pages 434-445
Journal: Environmental Research - Volume 152, January 2017, Pages 434-445
نویسندگان
Alfred B. Kobal, Janja Snoj Tratnik, Darja Mazej, Vesna Fajon, Darija GibiÄar, Ana MiklavÄiÄ, David Kocman, Jože Kotnik, Alenka SeÅ¡ek BriÅ¡ki, JoÅ¡ko Osredkar, Mladen Krsnik, Marija Prezelj, Ärtomir Knap, Bojana Križaj, Lian Liang, Milena Horvat,