The role of cytochrome P4501A activity inhibition in three- to five-ringed polycyclic aromatic hydrocarbons embryotoxicity of marine medaka (Oryzias melastigma)

► The mode of action of PAHs to cause the fish developmental malformation is unclear. ► Toxicity of Phe in O. melastigma embryo may be caused through narcosis mechanism. ► There may be a protective role of CYP1A enzyme activity in BSD caused by Py. ► BaP embryotoxicity may be caused by parent compound and not its metabolites.