کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6491372 | 43410 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptome analyses to understand effects of the Fusarium deoxynivalenol and nivalenol mycotoxins on Escherichia coli
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کلمات کلیدی
DeoxynivalenolphenylacetateATARPKMNIVFHBFB1Fusarium graminearumE. coliRT-PCRNCBIKEGGPAAACNRNA-seqF. graminearumAFB1 - AFB 1Aflatoxin B1 - آفلاتوکسین B1Acetonitrile - استونیتریلEscherichia coli - اشریشیا کُلیRNA sequencing - ترتیب RNAKyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوDON - دونFusarium head blight - سر Fusarium سرگیجه داردDEG - شماFumonisin B1 - فومونیزین B1Luria-Bertani - لواریا بارتانیNational Center for Biotechnology Information - مرکز ملی اطلاعات بیوتکنولوژیMycotoxin - میوکوتوکسینNivalenol - نیبولنولGene ontology - هستیشناسی ژنیreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوسoptical density - چگالی نوریDifferentially expressed gene - ژن بیان شده متفاوت است
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fusarium spp. cause many diseases in farming systems and can produce diverse mycotoxins that can easily impact humans and animals through the ingestion of food and feed. Among these mycotoxins, deoxynivalenol (DON) and nivalenol (NIV) are considered the most important hazards because they can rapidly diffuse into cells and block eukaryotic ribosomes, leading to inhibition of the translation system. Conversely, the effects of DON and NIV mycotoxins on bacteria remain unclear. We employed RNA-seq technology to obtain information regarding the biological responses of bacteria and putative bacterial mechanisms of resistance to DON and NIV mycotoxins. Most differentially expressed genes down-regulated in response to these mycotoxins were commonly involved in phenylalanine metabolism, glyoxylate cycle, and cytochrome o ubiquinol oxidase systems. In addition, we generated an overall network of 1028 up-regulated genes to identify core genes under DON and NIV conditions. The results of our study provide a snapshot view of the transcriptome of Escherichia coli K-12 under DON and NIV conditions. Furthermore, the information provided herein will be useful for development of methods to detect DON and NIV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 192, Part A, 20 December 2014, Pages 231-239
Journal: Journal of Biotechnology - Volume 192, Part A, 20 December 2014, Pages 231-239
نویسندگان
Jungwook Park, Hyun-Hee Lee, Kihoon Youn, Sunyoung Kim, Boknam Jung, Jungkwan Lee, Young-Su Seo,