کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7270749 | 1473241 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treatment of fibromyalgia syndrome with gabapentin and pregabalin - A meta-analysis of randomized controlled trials
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The efficacy of gabapentin (GPT) and pregabalin (PGB) in the treatment of fibromyalgia syndrome (FMS) was assessed. We screened MEDLINE, PsycINFO, SCOPUS, www.clinicaltrials.org, the Cochrane Library (through October 2008), and the reference sections of original studies on GPT/PGB in FMS. Randomized controlled trials (RCTs) on the treatment of FMS with GPT and PGB were analyzed. Six out of 127 RCTs studying 2422 subjects on treatment with GPT (one study) or PGB (five studies) and 1056 subjects on placebo with a median treatment duration of 11 weeks were included into the systematic review. Five studies were suitable for meta-analysis. Effects were summarized using standardized mean differences (SMD). There was strong evidence for a reduction of pain (SMD -0.28, 95% CI â0.36, â0.20; p < 0.001), improved sleep (SMD â0.39, 95% CI â0.48, â0.39; p < 0.001), and improved health-related quality of life (HRQOL) (SMD â0.30, 95% CI â0.46, â0.15; p < 0.001), but not for depressed mood (SMD â0.12, 95% CI â0.30, 0.06; p = 0.18). There was strong evidence for a non-substantial reduction of fatigue (SMD â0.16, 95% CI â0.23, â0.09, p < 0.001) and of anxiety (SMD â0.18, 95% CI â0.27, â0.10; p < 0.001). The external validity of the studies was limited because patients with severe somatic and mental disorders were excluded.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN® - Volume 145, Issues 1â2, September 2009, Pages 69-81
Journal: PAIN® - Volume 145, Issues 1â2, September 2009, Pages 69-81
نویسندگان
Winfried Häuser, Kathrin Bernardy, Nurcan Ãçeyler, Claudia Sommer,