Multi-response optimization of magnetic solid phase extraction based on carbon coated Fe3O4 nanoparticles using desirability function approach for the determination of the organophosphorus pesticides in aquatic samples by HPLC-UV

► Fe3O4/C MNPs were synthesized by a simple hydrothermal reaction. ► Fe3O4/C MNPs were used as an adsorbent for magnetic solid phase extraction (MSPE). ► Central composite design combined with desirability function used for optimization. ► Proposed method exhibits wider linear ranges, lower LODs and good reproducibility. ► High enrichment factors in the range of 330-1200 were obtained for the OPPs.