کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7782723 | 1500566 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities
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کلمات کلیدی
Algae polysaccharidesMLEVMALLSMHVDepolymerizationSECDPPHchondroitin sulfate C2,2-diphenyl-1-picrylhydrazyl radical - 2،2-دیفنیل-1-پریکیل هیدرازیل رادیکالHydrogen peroxide - آب اکسیژنهDegradation - تنزلHydrodynamic volume - حجم هیدرودینامیکیdegree of sulfation - درجه سولفاتHydrothermal treatment - درمان هیدروترمالFTIR - طیف سنج مادون قرمزFourier transform infrared spectroscopy - طیف سنجی مادون قرمز تبدیل فوریه یا طیف سنجی FTIRFucoidan - فوکودین یا ﻓﻮﻛﻮﺋﻴﺪانH2O2 - هیدروژن پراکسیدmulti-angle laser light scattering - پراکندگی نور لیزر چند زاویهSize exclusion chromatography - کروماتوگرافی اندازهای طردی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities](/preview/png/7782723.png)
چکیده انگلیسی
The fucose-containing sulfated polysaccharides (syn. fucoidans) from brown algae exhibit a wide range of bioactivities and are therefore considered promising candidates for health-supporting and medical applications. During the past three decades, research on isolation, molecular characterization, and screening of in vitro and in vivo pharmacological activities has significantly increased. Until now, however, fucoidans are only used as ingredients in cosmetics and food supplements, especially due to the proclaimed antioxidant activities of fucoidan. One obstacle to medical applications is the usually high molecular mass of native fucoidans, as it is associated with unfavorable biopharmaceutical properties and possibly undesired effects. Therefore, it seems reasonable to develop fucoidan derivatives with reduced size. So far, in this study, fucoidan from Fucus vesiculosus was gradually degraded from Mw 38.2 down to 4.9â¯kDa without concomitant desulfation. Compared to hydrothermal treatment, the degradation with H2O2 showed to be more efficient and additionally eliminated the antioxidant and antiproliferative activities of the genuine fucoidan. This confirmed our previous hypothesis that rather co-extracted compounds like terpenoids and polyphenols than the fucoidan itself exhibit these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 208-216
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 208-216
نویسندگان
Eric Lahrsen, Inga Liewert, Susanne Alban,