کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7786605 1500622 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purification, characterization and hepatoprotective activities of mycelia zinc polysaccharides by Pleurotus djamor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Purification, characterization and hepatoprotective activities of mycelia zinc polysaccharides by Pleurotus djamor
چکیده انگلیسی
This study was designed to investigate the physicochemical properties (molecular weights, bond types and monosaccharide compositions), antioxidant activities, and hepatoprotective effects on carbon tetrachloride (CCl4)-induced acute liver damage of mycelia zinc polysaccharides (MZPSs) and its major fractions (MZPS-1, -2 and -3) separated from Pleurotus djamor. In vitro assays, the MZPS-3 demonstrated relatively strong antioxidant activities in dose-dependent manners. For in vivo hepatoprotective activities, administration of MZPS-3 at 800 mg/kg significantly decreased the levels of AST, ALT, MDA and LPO, remarkably increased the levels of TC, TG and ALB, and prominently restored the activities of SOD, GSH-Px, CAT and T-AOC in serum/liver homogenate against CCl4-induced injures. Findings presented in this study clearly demonstrated that MZPSs, especially MZPS-3, might be suitable for functional foods and natural drugs in preventing the CCl4-induced acute liver damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 136, 20 January 2016, Pages 588-597
نویسندگان
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