کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7789544 1500641 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles
چکیده انگلیسی
β-Carotene (β-C) is a well-established natural antioxidant agent, but its poor water-solubility, low chemical stability and low bioavailability limit its application in food, pharmaceuticals and cosmetics industries. Thus it is critical to develop an efficient method to improve the water solubility and stability of β-C. In this research, amphiphilic chitosan-graft-poly (lactide) (CS-g-PLA) copolymer was synthesized via a homogeneous ring-opening polymerization (ROP) in ionic liquid. The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and β-C loaded micelles (β-C/M) had low β-C degradation after 15 days. The antioxidant properties of the β-C/M were investigated by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method, respectively. Significantly improved antioxidant activity was observed for β-C/M in compare with free β-C. The aqueous dispersion of β-C/M has potential to be applied in the field of functional food and cosmetics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 117, 6 March 2015, Pages 169-176
نویسندگان
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