کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8258365 1534602 2018 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The yeast replicative aging model
ترجمه فارسی عنوان
مدل پیری تکثیر کننده مخمر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
It has been nearly three decades since the budding yeast Saccharomyces cerevisiae became a significant model organism for aging research and it has emerged as both simple and powerful. The replicative aging assay, which interrogates the number of times a “mother” cell can divide and produce “daughters”, has been a stalwart in these studies, and genetic approaches have led to the identification of hundreds of genes impacting lifespan. More recently, cell biological and biochemical approaches have been developed to determine how cellular processes become altered with age. Together, the tools are in place to develop a holistic view of aging in this single-celled organism. Here, we summarize the current state of understanding of yeast replicative aging with a focus on the recent studies that shed new light on how aging pathways interact to modulate lifespan in yeast.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1864, Issue 9, Part A, September 2018, Pages 2690-2696
نویسندگان
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