کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8260425 1534662 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New methodologies for studying lipid synthesis and turnover: Looking backwards to enable moving forwards
ترجمه فارسی عنوان
روشهای جدید برای مطالعه سنتز لیپید و گردش: نگاه کردن به عقب برای فعال کردن حرکت به جلو
کلمات کلیدی
ایزوتوپهای پایدار، طیف سنجی جرمی، بیومارکر جنبشی، دیسپیدمی، بیماری قلب و عروقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Our ability to understand the pathogenesis of problems surrounding lipid accretion requires attention towards quantifying lipid kinetics. In addition, studies of metabolic flux should also help unravel mechanisms that lead to imbalances in inter-organ lipid trafficking which contribute to dyslipidemia and/or peripheral lipid accumulation (e.g. hepatic fat deposits). This review aims to outline the development and use of novel methods for studying lipid kinetics in vivo. Although our focus is directed towards some of the approaches that are currently reported in the literature, we include a discussion of the older literature in order to put “new” methods in better perspective and inform readers of valuable historical research. Presumably, future advances in understanding lipid dynamics will benefit from a careful consideration of the past efforts, where possible we have tried to identify seminal papers or those that provide clear data to emphasize essential points. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 3, March 2014, Pages 402-413
نویسندگان
, , , , , , , , , , , , ,