کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8260667 | 1534665 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response
ترجمه فارسی عنوان
یک فرضیه جدید برای مکانیسم 'نجات' قلیایی فسفاتاز در پاسخ ایمنی فاز حاد کبدی
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کلمات کلیدی
GPiasialoorosomucoidASORASGP-RGCAPFcγRIIbFcγRFVIIIASNFcRnIAPCFTRADPAE2BDLCRDDAMPCysALADICAMPcyclic AMP - AMP cycliccAMP - cAMPAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPadenosine diphosphate - آدنوزین دی فسفاتadenosine monophosphate - آدنوزین مونوفسفرهArginine - آرژنین Asparagine - آسپاراژینalanine - آلانینAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییArg - ارگdamage-associated molecular pattern - الگوی مولکولی مرتبط با آسیبdisseminated intravascular coagulation - انعقاد داخل عضلانی منتشر شده استCABG - جراحی کنارگذر سرخرگ تاجیCurl - حلقهcarbohydrate recognition domain - دامنه شناخت کربوهیدراتcystic fibrosis transmembrane conductance regulator - رگولاتور رسانایی فرابنفش فیبروز کیستیکCysteine - سیستئینFab - فابFactor VIII - فاکتور 8anion exchanger 2 - مبدل آنی 2Coronary artery bypass graft - پیوند عروق کرونرbile duct ligation - پیوند مجرای صفراویGly - گلیGlycine - گلیسینglycosylphosphatidylinositol - گلیکوزیل فسفاتیدیلینوزیتولAsialoglycoprotein receptor - گیرنده Asialoglycoproteinneonatal Fc receptor - گیرنده Fc نوزادانFc gamma receptor - گیرنده گاما Fc
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
The liver isoform of the enzyme alkaline phosphatase (AP) has been used classically as a serum biomarker for hepatic disease states such as hepatitis, steatosis, cirrhosis, drug-induced liver injury, and hepatocellular carcinoma. Recent studies have demonstrated a more general anti-inflammatory role for AP, as it is capable of dephosphorylating potentially deleterious molecules such as nucleotide phosphates, the pathogenic endotoxin lipopolysaccharide (LPS), and the contact clotting pathway activator polyphosphate (polyP), thereby reducing inflammation and coagulopathy systemically. Yet the mechanism underlying the observed increase in liver AP levels in circulation during inflammatory insults is largely unknown. This paper hypothesizes an immunological role for AP in the liver and the potential of this system for damping generalized inflammation along with a wide range of ancillary pathologies. Based on the provided framework, a mechanism is proposed in which AP undergoes transcytosis in hepatocytes from the canalicular membrane to the sinusoidal membrane during inflammation and the enzyme's expression is upregulated as a result. Through a tightly controlled, nucleotide-stimulated negative feedback process, AP is transported in this model as an immune complex with immunoglobulin G by the asialoglycoprotein receptor through the cell and secreted into the serum, likely using the receptor's State 1 pathway. The subsequent dephosphorylation of inflammatory stimuli by AP and uptake of the circulating immune complex by endothelial cells and macrophages may lead to decreased inflammation and coagulopathy while providing an early upstream signal for the induction of a number of anti-inflammatory gene products, including AP itself.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1832, Issue 12, December 2013, Pages 2044-2056
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1832, Issue 12, December 2013, Pages 2044-2056
نویسندگان
Adrianne F. Pike, Nynke I. Kramer, Bas J. Blaauboer, Willem Seinen, Ruud Brands,