کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8322578 | 1539878 | 2015 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional roles of non-coding Y RNAs
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کلمات کلیدی
Zbp1ORCMBTY RNARNPPNPasePTBsnRNAantisense morpholino oligonucleotidenuclear magnetic resonance - رزونانس مغناطیسی هستهایRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهNon-coding RNA - RNA غیرکد کننده، RNA غیرترجمه شوندهsmall nuclear RNA - RNA هسته ای کوچکUltraviolet - اشعه فرابنفشMid-blastula transition - انتقال میانی بلواستولNMR - تشدید مغناطیسی هستهای RNA stability - ثبات RNAcircular dichroism - رنگ تابی دورانیribonucleoprotein - ریبونولوپروتئینPolynucleotide phosphorylase - فسفوریلاس پولینوکلئوتیدDNA replication - همانندسازی DNA، تکثیر DNAPolypyrimidine tract-binding protein - پروتئین اتصال پروتئین Polypyrimidineorigin recognition complex - پیچیدگی شناخت اولیه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Non-coding RNAs are involved in a multitude of cellular processes but the biochemical function of many small non-coding RNAs remains unclear. The family of small non-coding Y RNAs is conserved in vertebrates and related RNAs are present in some prokaryotic species. Y RNAs are also homologous to the newly identified family of non-coding stem-bulge RNAs (sbRNAs) in nematodes, for which potential physiological functions are only now emerging. Y RNAs are essential for the initiation of chromosomal DNA replication in vertebrates and, when bound to the Ro60 protein, they are involved in RNA stability and cellular responses to stress in several eukaryotic and prokaryotic species. Additionally, short fragments of Y RNAs have recently been identified as abundant components in the blood and tissues of humans and other mammals, with potential diagnostic value. While the number of functional roles of Y RNAs is growing, it is becoming increasingly clear that the conserved structural domains of Y RNAs are essential for distinct cellular functions. Here, we review the biochemical functions associated with these structural RNA domains, as well as the functional conservation of Y RNAs in different species. The existing biochemical and structural evidence supports a domain model for these small non-coding RNAs that has direct implications for the modular evolution of functional non-coding RNAs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 66, September 2015, Pages 20-29
Journal: The International Journal of Biochemistry & Cell Biology - Volume 66, September 2015, Pages 20-29
نویسندگان
Madzia P. Kowalski, Torsten Krude,