کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8358757 | 1542142 | 2016 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracellular and extracellular microRNA: An update on localization and biological role
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کلمات کلیدی
miRISCpRNAILVESCRTMVBPTGSRNPHDLhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاRNA interference - RNA تداخل کنندهSmall interfering RNA - RNA تداخل کوچکRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهsiRNA - siRNAintraluminal vesicles - vesicles intraluminalExosomes - اگزوزوم هاmultivesicular bodies - بدن مولکولیCirculating microRNA - توزیع میکرو RNApost-transcriptional gene silencing - خاموش کردن ژن post-transcriptionalRISC - خطرCancer - سرطانendoplasmic reticulum - شبکه آندوپلاسمی endosomal sorting complex required for transport - مجتمع مرتب سازی آندوسومی مورد نیاز برای حمل و نقلMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAArgonaute proteins - پروتئین های آرگونوتAGO - پیش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
MicroRNA (miRNA) is a class of small non-coding RNAs which mediate post-transcriptional gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or lowering their half-lives in the cytoplasm. Together with their binding partners, Argonaute (AGO) proteins, miRNAs form cores of RNA-induced silencing complexes (RISC). Despite a substantial progress in understanding RISC structure, until recently little was known about its localization in the cell. This review is aimed to provide an overview of the emerging picture of miRNA and RISC localization and function both in the intracellular space and outside of the cell. In contrast to the common assumption that PTGS occurs in the cytoplasm, it was found to operate mainly on the membranes of the endoplasmic reticulum (ER). Besides ER membranes miRNAs were found in all main cellular compartments including nucleus, nucleolus and mitochondria where they regulate various processes including transcription, translation, alternative splicing and DNA repair. Moreover, a certain pool of miRNAs may not be associated with RISC and carry completely different functions. Finally, the discovery of cell-free miRNAs in all biological fluids suggests that miRNAs might also act as signaling molecules outside the cell, and may be utilized as biomarkers for a variety of diseases. In this review we discuss miRNA secretion mechanisms and possible pathways of cell-cell communication via miRNA-containing exosomes in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Histochemistry and Cytochemistry - Volume 51, Issues 3â4, November 2016, Pages 33-49
Journal: Progress in Histochemistry and Cytochemistry - Volume 51, Issues 3â4, November 2016, Pages 33-49
نویسندگان
Julia A. Makarova, Maxim U. Shkurnikov, Daniel Wicklein, Tobias Lange, Timur R. Samatov, Andrey A. Turchinovich, Alexander G. Tonevitsky,