کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8358894 | 1542167 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides
ترجمه فارسی عنوان
مسیرهای سنتز و تخریب، عملکردها و آسیب شناسی سرامید و آسیکلرامید های اپیدرمی
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کلمات کلیدی
KDSaCSFS1PCLEABCULCLCBGlcCerACSLACSVLGalCerphytosphingosinedihydrosphingosineARCIX-linked adrenoleukodystrophyLacCerX-ALDACSSSTGD3Dihydrosphingosine 1-phosphateVLCAcylceramideACSBGSjögren-Larsson syndromeLCBPACSMALDHSPHSLSVLCFAACSFASLCFACOOHBATSPTAldehyde - آلدهیدacyl-CoA synthetase - Acyl-CoA Synthetaseautosomal recessive congenital ichthyosis - ichthyosis مادرزادی اتوزومی مغلوبaldehyde dehydrogenase - آلدئید دهیدروژنازsphingomyelin - اسفنگومیلینsphingosine 1-phosphate - اسپینگزین 1-فسفاتsphingosine - اسپینگوزینsphingolipid - اسپینگولایپیدFatty acid - اسید چربVery-long-chain fatty acid - اسید چرب بسیار زنجیره ایfatty acid synthase - اسید چرب سنتازLong-chain fatty acid - اسید چرب طولانی مدتPolyunsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعCarboxylic acid - اسید کربوکسیلیکbrown adipose tissue - بافت چربی قهوه ایCho - برایDihydroceramide - دی هیدروکرامیدlong-chain - زنجیره طولانیMedium-chain - زنجیره متوسطCer - سرceramide - سرامیدendoplasmic reticulum - شبکه آندوپلاسمی phosphatidylcholine - فسفاتیدیل کولینPhytoceramide - فیتوسرامیدlactosylceramide - لاکتوزیلسرامیدskin barrier - مانع پوستیknockout - ناکاوتcornified envelope - پاکت زده شدهlong-chain base - پایه زنجیره طولانیSerine palmitoyltransferase - پریتیمویل ترانسفراز SerineATP-binding cassette - کیت اتصال به ATPgalactosylceramide - گالاکتوسیلسرامیدglucosylceramide - گلوکوزیلسرامید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Ceramide (Cer) is a structural backbone of sphingolipids and is composed of a long-chain base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length, hydroxylation status, and/or double bond number of either of their hydrophobic chains, has been reported. Ceramide is produced by Cer synthases. Mammals have six Cer synthases (CERS1-6), each of which exhibits characteristic substrate specificity toward acyl-CoAs with different chain-lengths. Knockout mice for each Cer synthase show corresponding, isozyme-specific phenotypes, revealing the functional differences of Cers with different chain-lengths. Cer diversity is especially prominent in epidermis. Changes in Cer levels, composition, and chain-lengths are associated with atopic dermatitis. Acylceramide (acyl-Cer) specifically exists in epidermis and plays an essential role in skin permeability barrier formation. Accordingly, defects in acyl-Cer synthesis cause the cutaneous disorder ichthyosis with accompanying severe skin barrier defects. Although the molecular mechanism by which acyl-Cer is generated was long unclear, most genes involved in its synthesis have been identified recently. In Cer degradation pathways, the long-chain base moiety of Cer is converted to acyl-CoA, which is then incorporated mainly into glycerophospholipids. This pathway generates the lipid mediator sphingosine 1-phosphate. This review will focus on recent advances in our understanding of the synthesis and degradation pathways, physiological functions, and pathology of Cers/acyl-Cers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 63, July 2016, Pages 50-69
Journal: Progress in Lipid Research - Volume 63, July 2016, Pages 50-69
نویسندگان
Akio Kihara,