کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8491104 | 1552353 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs
ترجمه فارسی عنوان
اثرات ایمن سازی پروبیوتیک ها برای مدولاسیون میکروبیوتا، سلامت روده و مقاومت بیماری در خوک ها
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کلمات کلیدی
TregsGM-CSFTEERHspLGGFOSGOSSCFAMCP-1Lactobacillus rhamnosus GGGITETECZO-1VSVEPSIPEC-J2IPEC-1LPSCFUenterotoxigenic E. coli - Enterotoxigenic E. coliMAPK - MAPKregulatory T-cells - T-cell های نظارتیShort chain fatty acids - اسیدهای چرب پایه کوتاهImmunomodulation - تنظیم ایمنی tumor necrosis factor-α - تومور نکروز عامل αGastrointestinal tract - دستگاه گوارشRotavirus - روتاویروس Gut health - سلامت خوبTNF-α - فاکتور نکروز توموری آلفاfructo-oligosaccharide - فروکتلوژیاکاردارlipopolysaccharide - لیپوپلی ساکاریدgranulocyte macrophage colony-stimulating factor - ماکروفاژ گرانولوسیت عامل کلونی تحریک کنندهtransepithelial electrical resistance - مقاومت الکتریکی transepithelialGut microbiota - میکروبی خوب استZonula occludens-1 - نوار ابزار بسته 1colony forming units - واحدهای تشکیل دهنده کلنیVesicular stomatitis virus - ویروس vesicular stomatitisPie - پایProbiotics - پروبیوتیکHeat shock protein - پروتئین شوک حرارتmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1mitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPrebiotics - پری بیوتیک ها Extracellular polysaccharide - پلی ساکارید خارج سلولیgalacto-oligosaccharide - گالاکتو الیگوساکارید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Probiotics are live microorganisms that can confer a health benefit on the host, and amongst various mechanisms probiotics are believed to exert their effects by production of antimicrobial substances, competition with pathogens for adhesion sites and nutrients, enhancement of mucosal barrier integrity and immune modulation. Through these activities probiotics can support three core benefits for the host: supporting a healthy gut microbiota, a healthy digestive tract and a healthy immune system. More recently, the concept of combining probiotics and prebiotics, i.e. synbiotics, for the beneficial effect on gut health of pigs has attracted major interest, and examples of probiotic and prebiotic benefits for pigs are pathogen inhibition and immunomodulation. Yet, it remains to be defined in pigs, what exactly is a healthy gut. Because of the high level of variability in growth and feed conversion between individual pigs in commercial production systems, measuring the impact of probiotics on gut health defined by improvements in overall productivity requires large experiments. For this reason, many studies have concentrated on measuring the effects of the feed additives on proxies of gut health including many immunological measures, in more controlled experiments. With the major focus of studying the balance between gut microbiology, immunology and physiology, and the potential for prevention of intestinal disorders in pigs, we therefore performed a literature review of the immunomodulatory effects of probiotics, either alone or in combination with prebiotics, based on in vivo, in vitro and ex vivo porcine experiments. A consistent number of studies showed the potential capacity in terms of immunomodulatory activities of these feed additives in pigs, but contrasting results can also be obtained from the literature. Reasons for this are not clear but could be related to differences with respect to the probiotic strain used, experimental settings, diets, initial microbiota colonization, administration route, time and frequency of administration of the probiotic strain and sampling for analysis. Hence, the use of proxy measurements of enteric health based on observable immunological parameters presents significant problems at the moment, and cannot be considered robust, reliable predictors of the probiotic activity in vivo, in relation to pig gut health. In conclusion, more detailed understanding of how to select and interpret these proxy measurements will be necessary in order to allow a more rational prediction of the effect of specific probiotic interventions in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Animal Feed Science and Technology - Volume 233, November 2017, Pages 104-119
Journal: Animal Feed Science and Technology - Volume 233, November 2017, Pages 104-119
نویسندگان
Marianna Roselli, Robert Pieper, Claire Rogel-Gaillard, Hugo de Vries, Mick Bailey, Hauke Smidt, Charlotte Lauridsen,