کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8526347 | 1557943 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice
ترجمه فارسی عنوان
اثر آنتی اکسیدان و ضد التهابی پلیمیرید در کولیت ناشی از سولفات سدیم کلسترول در موش سوری
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کلمات کلیدی
TNFαPLUIBDDAIGSH5-ASADSSCATATRPlumierideIEC-63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromideMPO - DFODMSO - DMSOMTT - MTTAtropine - آتروپینNaïve - آدم ساده5-Aminosalicylic acid - اسید 5 آمینوسالسیلیکinflammation - التهاب( توروم) Iridoid - ایریدیدInflammatory bowel disease - بیماریهای التهابی رودهOxidative stress - تنش اکسیداتیوDimethyl sulfoxide - دیمتیل سولفواکسیدSOD - سدintestinal epithelial cell - سلول های اپیتلیال رودهDextran sulfate sodium - سولفات سدیم دکسترانSuperoxide dismutase - سوکسوکس دیسموتازdisease activity index - شاخص فعالیت بیماریtumor necrosis factor - فاکتور نکروز تومورLOOH - لئوmyeloperoxidase - میلوپراکسیداز PAS - نهHematoxylin & Eosin - هماتوکسیلین و ائوزینlipid hydroperoxides - هیدروپراکسید لیپیدveh - وایVehicle - وسیله نقلیهCatalase - کاتالازreduced glutathione - کاهش گلوتاتیونUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
This study aimed to investigate the potential effect of plumieride, an iridoid glycoside isolated from Alamanda cathartica L. flowers, against dextran sulfate sodium (DSS)-induced colitis in mice. Colitis was induced in female swiss mice by adding DSS 3% to the drinking water. The animals were treated with vehicle (water), 5-aminosalicylic acid (100â¯mg/kg) or plumieride (10, 30 and 100â¯mg/kg) once a day, during 7 days. The body weight progression and the disease activity index was evaluated daily. On the eighth day, colons were collected for the measurement of the size, histological, histochemical, biochemical and inflammatory analysis. The cytotoxicity of plumieride on intestinal epithelial cell (IEC-6 cell line) was also evaluated. Plumieride, at dose of 100â¯mg/kg, significantly attenuated the mice weight loss, showed lower score in the disease activity index, diminished the colon shortening, improved the histological damage and avoided mucosa intestinal mucus depletion when compared with vehicle-treated only group. Moreover, plumieride was able to reduce the amount of colonic lipid hydroperoxides, while augmented reduced glutathione levels and superoxide dismutase activity. Although DSS intake stimulated an increase in myeloperoxidase activity and in tumor necrosis factor content on the colon tissue of the vehicle-treated group, the colons obtained from mice treated with plumieride did not present any of these changes. Taking together, the results of the present study disclose that plumieride exhibited a significant efficacy in attenuating the parameters of experimental ulcerative colitis, which may be mediated by an antioxidant and anti-inflammatory effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 99, March 2018, Pages 697-703
Journal: Biomedicine & Pharmacotherapy - Volume 99, March 2018, Pages 697-703
نویسندگان
Thaise Boeing, Priscila de Souza, Tiago José Bonomini, LuÃsa Nathália Bolda Mariano, Lincon Bordignon Somensi, Ruth Meri Lucinda, Angela Malheiros, LuÃsa Mota da Silva, Sérgio Faloni de Andrade,