کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537144 | 1561006 | 2019 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia
ترجمه فارسی عنوان
بیان ژن تغییرات مربوط به فرآیندهای ایمنی مرتبط با اندوفنوتایپ شناختی اسکیزوفرنی است
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کلمات کلیدی
CFIRMSEATLIEndophenotypesMCHHLA-GIPADISC1CVLTRTN4eIF2WAIS-RMCMCMAFhuman leukocyte antigen GFDRWMS-RCFASchizophrenia - اسکیزوفرنی یا شیزوفرنیImmune - ایمنیGene expression - بیان ژنConfirmatory Factor Analysis - تحلیل عاملی تاییدیRoot mean square error of approximation - ریشه میانگین خطای تقریبی مربعRIN - رینComparative Fit Index - شاخص مناسب مقایسهRNA Integrity Number - شماره یکپارچه RNACognition - شناختeukaryotic initiation factor-2 - عامل آغاز کننده یوکاریوتی 2minor allele frequency - فراوانی آللی جزئیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیStructural equation modelling - مدل سازی معادلات ساختاریSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیfalse discovery rate - میزان کشف کاذبNde1 - میلیونNogo - نگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Schizophrenia is a heterogeneous disorder characterized by a spectrum of symptoms and many different underlying causes. Thus, instead of using the broad diagnosis, intermediate phenotypes can be used to possibly decrease the underlying complexity of the disorder. Alongside the classical symptoms of delusions and hallucinations, cognitive deficits are a core feature of schizophrenia. To increase our understanding of the biological processes related to these cognitive deficits, we performed a genome-wide gene expression analysis. A battery of 14 neuropsychological tests was administered to 844 individuals from a Finnish familial schizophrenia cohort. We grouped the applied neuropsychological tests into five factors for further analysis. Cognitive endophenotypes, whole blood mRNA, genotype, and medication use data were studied from 47 individuals. Expression level of several RNA probes were significantly associated with cognitive performance. The factor representing Verbal Working Memory was associated with altered expression levels of 11 probes, of which one probe was also associated with a specific sub-measure of this factor (WMS-R Digit span backward). While, the factor Processing speed was related to one probe, which additionally associated among 55 probes with a specific sub-measure of this factor (WAIS-R Digit symbol). Two probes were associated with the measure recognition memory performance. Enrichment analysis of these differentially expressed probes highlighted immunological processes. Our findings are in line with genome-wide genetic discoveries made in schizophrenia, suggesting that immunological processes may be of biological interest for future drug design towards schizophrenia and the cognitive dysfunctions that underlie it.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 159-167
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 159-167
نویسندگان
Ukkola-Vuoti L., Torniainen-Holm M., Ortega-Alonso A., Sinha V., Tuulio-Henriksson A., Paunio T., Lönnqvist J., Suvisaari J., Hennah W.,