کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8544702 | 1561553 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RNA interference against stromal interacting molecule-1 (STIM1) ameliorates ethanol-induced hepatotoxicity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: RNA interference against stromal interacting molecule-1 (STIM1) ameliorates ethanol-induced hepatotoxicity RNA interference against stromal interacting molecule-1 (STIM1) ameliorates ethanol-induced hepatotoxicity](/preview/png/8544702.png)
چکیده انگلیسی
Previously we have demonstrated that stromal interacting molecule-1 (STIM1) was involved in ethanol induced liver injury. However, the exact pathogenic mechanism of STIM1 in alcoholic liver disease (ALD) is still unknown. We constructed plasmid vectors encoding short-hairpin RNA against STIM1 to investigate its role in ALD in the rat liver cell line BRL and in Sprague-Dawley rats. The results showed that STIM1 targeted sh-RNA (Sh-STIM1) significantly ameliorated ethanol-induced BRL cells injury and liver injury in rats with 20 weeks-induced alcoholic liver disease. Inhibition of STIM1 also reduced intracellular calcium ion concentration, reactive oxygen species (ROS) production, lipid peroxidation, NF-kappa B activation and TNF-α production under ethanol exposure. STIM1 may play an important role in the pathogenesis of alcoholic liver disease. Silencing STIM1 may be effective in preventing alcoholic liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 289, 1 June 2018, Pages 47-56
Journal: Chemico-Biological Interactions - Volume 289, 1 June 2018, Pages 47-56
نویسندگان
Ruibing Cui, Rong Li, Xiaolan Guo, Xiaoqing Jia, Ming Yan,