کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8544716 | 1561554 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
In this study, the antiproliferative activity of peanut skin procyanidins (PSP) and six fractions (PSP-1â¼6) isolated from PSP by several chromatographic steps on the human prostate cancer DU145â¯cells were evaluated. The results showed that PSP and PSP-1â¼6 significantly inhibited the proliferation of DU145â¯cells. PSP-2 was the most effective fraction, which was identified as procyanidin B3 mainly and procyanidin dimer [(E)C-luteolin or keampferol] secondarily. Moreover, the mechanism of antiproliferative activity of PSP-2 was investigated. It was observed that PSP-2 induced apoptotic cell death and cell cycle arrest at S phase in DU145â¯cells. PSP-2 caused the increase of intracellular ROS level and the decrease of Bcl-2/Bax ratio, and triggered the activation of p53 and caspases-3 in DU145â¯cells. Our findings demonstrated that procyanidins from peanut skin have the potential to be developed as an anti-prostate cancer agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 288, 25 May 2018, Pages 12-23
Journal: Chemico-Biological Interactions - Volume 288, 25 May 2018, Pages 12-23
نویسندگان
Liang Chen, Fangfang Yan, Wanbing Chen, Li Zhao, Jiuliang Zhang, Qun Lu, Rui Liu,