کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550753 | 1562104 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of dietary alpha-linolenic acid-enriched diacylglycerol oil on embryo/fetal development in rats
ترجمه فارسی عنوان
تأثیر روغن دی سیل گلیسرول غنی شده اسید آلفا لینولنیک بر رشد جنین / جنین در موش صحرایی
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کلمات کلیدی
SDGFDANaClONOAELOECDEPAALAGRASS.D. - SD.Arachidonic acid - اسید آراشیدونیکalpha-linolenic acid - اسید آلفا لینولنیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکalpha linolenic acid - اسید لینولنیک آلفاstandard deviation - انحراف معیارgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استTeratology - تراتولوژیtriacylglycerol - تری آسیل گلیسرول TAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولdiacylglycerol - دیسیل گلیسیرینDAG - روزgestation day - روز بارداریFlaxseed oil - روغن کتانFood and Drug Administration - سازمان غذا و داروOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیSodium hypochlorite - سدیم هیپوکلریتDevelopmental toxicity - سمیت توسعهFood ingredient - مواد غذاییno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Recent studies suggest that diets supplemented with alpha-linolenic acid (ALA)-enriched diacylglycerol (DAG) oil provide potential health benefits in preventing or managing obesity. However, available safety information about reproductive and developmental toxicities of ALA-DAG oil is limited. This study was conducted to clarify the effect, if any, of ALA-DAG oil on embryo-fetal development, following maternal exposure during the critical period of major organogenesis. ALA-DAG oil was administered via gavage to pre-mated female Sprague Dawley rats from gestation day 6 through 19, at dose levels of 0, 1.25, 2.5, and 5.0â¯mL/kg/day (equivalent to 0, 1149, 2325, and 4715â¯mg/kg/day, respectively), with total volume adjusted to 5â¯mL/kg/day with rapeseed oil. All females survived to the scheduled necropsy. There were no treatment-related changes in clinical or internal findings, maternal body weights, feed consumption, intrauterine growth, survival, and number of implantations. No ALA-DAG oil-related fetal malformations or developmental variations were noted. A maternal maximum tolerated dose for ALA-DAG oil could not be achieved in this study. Based on these results, a dose level of 5.0â¯mL/kg (4715â¯mg/kg/day), the highest dose tested, was considered as the no-observed-adverse-effect level (NOAEL) for both maternal and developmental toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 98, October 2018, Pages 108-114
Journal: Regulatory Toxicology and Pharmacology - Volume 98, October 2018, Pages 108-114
نویسندگان
Hiroto Bushita, Shujie Liu, Takafumi Ohta, Yuichi Ito, Kazutoshi Saito, Yuko Nukada, Naohiro Ikeda, Osamu Morita,