کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8633959 | 1569088 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central obesity and body fat, but not body mass index, are associated with the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ gene in a population with a high consumption of saturated and trans-fatty acids
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کلمات کلیدی
SFAPPAR γMUFAsWHRPUFAsPPARγTFAPALtrans-fatty acid - اسید ترانس چربsaturated fatty acid - اسید چرب اشباع شدهPolyunsaturated fatty acids - اسید چرب اشباع نشدهFatty acids - اسیدهای چربmonounsaturated fatty acids - اسیدهای چرب غیر اشباعHumans - انسانWorld Health Organization - سازمان بهداشت جهانیFood and Agriculture Organization - سازمان غذا و کشاورزیPhysical activity level - سطح فعالیت فیزیکیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیFAO - فائوconfidence interval - فاصله اطمینانObesity - مرض چاقیCross-sectional studies - مطالعات مقطعی waist-to-hip ratio - نسبت دور کمر به رانodds ratio - نسبت شانس هاBody fat - چربی بدنDietary fats - چربی های غذاییGenotype - ژنوتیپWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The relationship of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ (PPARγ) gene with obesity and its modulation by dietary fat has been proposed, but the few studies addressing this issue have yielded controversial results. In a Mexican population characterized by high-fat consumption, we hypothesized that the Pro12Ala PPARγ genotype is related to obesity and this relationship is modulated by intake of saturated fatty acids (SFAs) and trans-fatty acids (TFAs). We recruited 69 adults for this cross-sectional study. The Pro12Ala PPARγ polymorphism was determined from blood genomic DNA by using real-time polymerase chain reaction. Univariate and multivariate logistic regression analyses were performed. Pro12Ala showed a positive association with central obesity (adjusted odds ratio, 7.38; 95% confidence interval, 1.19-45.77; P = .032) and percentage of body fat (%BF; adjusted odds ratio, 1.08; 95% confidence interval, 1.00-1.17; P = .048), suggesting that Pro12Ala carriers are more likely to have central obesity and a higher %BF than Pro12Pro carriers. A modifying effect was observed for the SFAs strata: we found a significant association between the Pro12Ala polymorphism and %BF in the high-SFA-intake stratum (P < .04), but not in the low-intake stratum (P > .7). No modifying effect was observed for the TFAs strata. In addition, the impact of total energy intake on obesity in Pro12Ala carriers seemed to be stronger than that in the wild-type genotype carriers. As hypothesized, our data demonstrated a relationship between the Pro12Ala PPARγ polymorphism and the presence of obesity, which is modulated by SFA intake but not TFA intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 57, September 2018, Pages 28-35
Journal: Nutrition Research - Volume 57, September 2018, Pages 28-35
نویسندگان
Josefina Aguayo-Armendáriz, Maricela Montalvo-Corral, Karla A. González-MartÃnez, MarÃa I. Grijalva-Haro, Martha N. Ballesteros-Vásquez, Graciela Caire-Juvera, Silvia Y. Moya-Camarena,